Upstream Bio (UPB)
Upstream Bio on one page: short interest, daily short volume, fails to deliver, large holders, 13F holders, earnings dates and insider trades. Listed on Nasdaq.
4.5M
Short interest
settlement 2026-10-15
3.7
Days to cover
-4.0 days vs prior
8.3%
Short share of volume
2026-11-02
800
Fails to deliver
settlement 2026-10-13
Wed 4 Nov
Next earnings
estimated date
-$28K
Insider flow, 90 days
0 buys, 5 sells
As of 2026-11-02.
Short interest
FINRA, twice a month. The newest 48 settlements in the table, 48 in the chart. JSONAs of 15 October 2026, short interest in UPB is 4,480,785 shares, down 9,939 shares over the last month. Over the last 48 readings it ranged from 647,123 shares (31 October 2024) to 4,752,354 shares (13 March 2026). The latest reading sits at the top of that range. At the reported average volume of 1.2M shares a day that is 3.7 days to cover.
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| Settlement | Shares short | Change | Avg daily volume | Days to cover |
|---|---|---|---|---|
| 2026-10-15 | 4,480,785 | -0.8% | 1,215,658 | 3.69 |
| 2026-09-30 | 4,514,865 | +0.5% | 587,966 | 7.68 |
| 2026-09-15 | 4,490,724 | +9.7% | 656,192 | 6.84 |
| 2026-08-31 | 4,095,011 | +1.9% | 549,503 | 7.45 |
| 2026-08-14 | 4,016,614 | +10.1% | 712,393 | 5.64 |
| 2026-07-31 | 3,648,558 | +0.8% | 486,961 | 7.49 |
| 2026-07-15 | 3,618,151 | -11.9% | 442,098 | 8.18 |
| 2026-06-30 | 4,105,630 | +5.3% | 718,338 | 5.72 |
| 2026-06-15 | 3,898,229 | +7.1% | 711,476 | 5.48 |
| 2026-05-29 | 3,640,867 | +7.2% | 534,404 | 6.81 |
| 2026-05-15 | 3,397,759 | +5.4% | 507,812 | 6.69 |
| 2026-04-30 | 3,223,622 | +6.6% | 564,193 | 5.71 |
| 2026-04-15 | 3,022,894 | -12.0% | 576,870 | 5.24 |
| 2026-03-31 | 3,435,261 | -27.7% | 991,750 | 3.46 |
| 2026-03-13 | 4,752,354 | +16.3% | 1,071,464 | 4.44 |
| 2026-02-27 | 4,086,377 | +15.8% | 2,232,151 | 1.83 |
| 2026-02-13 | 3,529,797 | +10.9% | 2,319,852 | 1.52 |
| 2026-01-30 | 3,183,884 | -7.8% | 574,390 | 5.54 |
| 2026-01-15 | 3,451,544 | -1.0% | 652,307 | 5.29 |
| 2025-12-31 | 3,486,600 | +16.9% | 606,049 | 5.75 |
| 2025-12-15 | 2,983,568 | +7.6% | 534,387 | 5.58 |
| 2025-11-28 | 2,773,635 | -7.4% | 541,286 | 5.12 |
| 2025-11-14 | 2,994,056 | +2.2% | 383,301 | 7.81 |
| 2025-10-31 | 2,929,476 | -12.2% | 371,545 | 7.88 |
| 2025-10-15 | 3,336,913 | -6.4% | 324,798 | 10.27 |
| 2025-09-30 | 3,564,217 | +18.4% | 553,826 | 6.44 |
| 2025-09-15 | 3,011,653 | -2.8% | 662,706 | 4.54 |
| 2025-08-29 | 3,097,969 | -2.0% | 352,910 | 8.78 |
| 2025-08-15 | 3,160,080 | +2.6% | 491,406 | 6.43 |
| 2025-07-31 | 3,080,800 | -18.5% | 536,114 | 5.75 |
| 2025-07-15 | 3,781,146 | -8.0% | 267,653 | 14.13 |
| 2025-06-30 | 4,109,973 | +13.8% | 718,695 | 5.72 |
| 2025-06-13 | 3,610,360 | -2.0% | 358,842 | 10.06 |
| 2025-05-30 | 3,685,383 | -1.6% | 386,027 | 9.55 |
| 2025-05-15 | 3,746,059 | -4.9% | 362,949 | 10.32 |
| 2025-04-30 | 3,940,057 | -3.1% | 296,778 | 13.28 |
| 2025-04-15 | 4,067,418 | +4.4% | 299,907 | 13.56 |
| 2025-03-31 | 3,895,476 | +4.9% | 250,957 | 15.52 |
| 2025-03-14 | 3,712,999 | +0.3% | 231,283 | 16.05 |
| 2025-02-28 | 3,702,588 | +6.9% | 212,383 | 17.43 |
| 2025-02-14 | 3,462,980 | +27.4% | 292,627 | 11.83 |
| 2025-01-31 | 2,717,049 | +13.6% | 240,686 | 11.29 |
| 2025-01-15 | 2,392,790 | +3.9% | 254,444 | 9.40 |
| 2024-12-31 | 2,302,003 | +89.0% | 645,702 | 3.57 |
| 2024-12-13 | 1,217,828 | +1.0% | 231,829 | 5.25 |
| 2024-11-29 | 1,205,876 | +16.0% | 246,933 | 4.88 |
| 2024-11-15 | 1,039,477 | +60.6% | 241,419 | 4.31 |
| 2024-10-31 | 647,123 | +180.5% | 342,967 | 1.89 |
Daily short volume
FINRA Reg SHO, the last 30 sessions. JSONAs of 2 November 2026, the short share of UPB volume is 8.3%, down 21.9 points over the last five sessions. Over the last 30 readings it ranged from 6.1% (30 October 2026) to 49.6% (24 September 2026). The latest reading sits at the bottom of that range. The latest reading is 17.1 points below the 30-session average of 25.4%, on 299K shares reported.
| Date | Short volume | Total volume | Short share | Exempt |
|---|---|---|---|---|
| 2026-11-02 | 25K | 299K | 8.3% | 0 |
| 2026-10-30 | 22K | 362K | 6.1% | 0 |
| 2026-10-29 | 87K | 430K | 20.3% | 0 |
| 2026-10-28 | 72K | 406K | 17.7% | 0 |
| 2026-10-27 | 97K | 518K | 18.6% | 50 |
| 2026-10-26 | 134K | 443K | 30.2% | 1,550 |
| 2026-10-23 | 190K | 500K | 37.9% | 48 |
| 2026-10-22 | 216K | 745K | 29.0% | 237 |
| 2026-10-21 | 136K | 538K | 25.2% | 0 |
| 2026-10-20 | 116K | 879K | 13.2% | 100 |
| 2026-10-19 | 185K | 757K | 24.5% | 3,810 |
| 2026-10-16 | 192K | 846K | 22.7% | 1,146 |
| 2026-10-15 | 118K | 539K | 21.9% | 0 |
| 2026-10-14 | 88K | 566K | 15.6% | 43 |
| 2026-10-13 | 92K | 452K | 20.4% | 2,196 |
| 2026-10-12 | 57K | 293K | 19.5% | 1,235 |
| 2026-10-09 | 71K | 460K | 15.5% | 0 |
| 2026-10-08 | 111K | 1.1M | 10.1% | 0 |
| 2026-10-07 | 80K | 327K | 24.6% | 0 |
| 2026-10-06 | 83K | 427K | 19.3% | 633 |
| 2026-10-05 | 121K | 405K | 29.9% | 110 |
| 2026-10-02 | 127K | 304K | 41.7% | 0 |
| 2026-10-01 | 84K | 283K | 29.6% | 0 |
| 2026-09-30 | 75K | 270K | 27.6% | 0 |
| 2026-09-29 | 84K | 408K | 20.5% | 0 |
| 2026-09-28 | 116K | 282K | 40.9% | 0 |
| 2026-09-25 | 66K | 149K | 44.3% | 0 |
| 2026-09-24 | 76K | 153K | 49.6% | 0 |
| 2026-09-23 | 69K | 211K | 32.6% | 7 |
| 2026-09-22 | 66K | 145K | 45.6% | 0 |
Fails to deliver
SEC, the last 30 settlement dates with a fail. JSONAs of 13 October 2026, the fails-to-deliver balance in UPB is 800 shares, down 9,312 shares over the last settlement date. Over the last 30 readings it ranged from 5 shares (20 April 2026) to 46,490 shares (23 March 2026). The latest reading sits at the bottom of that range.
| Settlement | Shares failed | Price | Value |
|---|---|---|---|
| 2026-10-13 | 800 | $4.17 | $3K |
| 2026-10-05 | 10,112 | $5.04 | $51K |
| 2026-10-02 | 7,300 | $5.04 | $37K |
| 2026-08-31 | 704 | $6.69 | $5K |
| 2026-08-25 | 4,012 | $6.61 | $27K |
| 2026-08-04 | 2,833 | $6.42 | $18K |
| 2026-07-23 | 7,554 | $6.59 | $50K |
| 2026-07-09 | 1,565 | $7.98 | $12K |
| 2026-07-08 | 4,421 | $7.86 | $35K |
| 2026-06-30 | 16,799 | $6.93 | $116K |
| 2026-06-29 | 773 | $6.75 | $5K |
| 2026-06-26 | 342 | $6.36 | $2K |
| 2026-06-22 | 348 | $6.25 | $2K |
| 2026-06-15 | 9,649 | $6.10 | $59K |
| 2026-06-04 | 30,472 | $7.63 | $233K |
| 2026-05-22 | 41,726 | $8.46 | $353K |
| 2026-05-21 | 2,321 | $8.41 | $20K |
| 2026-05-14 | 2,747 | $9.36 | $26K |
| 2026-05-11 | 417 | $9.09 | $4K |
| 2026-04-20 | 5 | $9.99 | $50 |
| 2026-04-06 | 13,236 | $9.50 | $126K |
| 2026-04-02 | 1,141 | $9.31 | $11K |
| 2026-03-26 | 12,209 | $9.47 | $116K |
| 2026-03-24 | 1,640 | $8.45 | $14K |
| 2026-03-23 | 46,490 | $8.67 | $403K |
| 2026-03-13 | 34,516 | $9.44 | $326K |
| 2026-03-12 | 7,764 | $9.36 | $73K |
| 2026-03-11 | 14,283 | $8.12 | $116K |
| 2026-03-10 | 42,865 | $8.06 | $345K |
| 2026-03-09 | 4,242 | $7.66 | $32K |
Insider trades
SEC Form 4, newest first. JSONInsiders at UPB reported 5 open-market sells worth $28K in the last 90 days and no open-market buys. Latest filing: Sutherland Everett Rand (Chief Executive Officer) on 2026-09-16.
| Date | Insider | Title | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|---|
| 2026-09-16 | Sutherland Everett Rand | Chief Executive Officer | Sell | 2K | $5.49 | $12K | 69K |
| 2026-09-16 | Houghton Adam | Chief Business Officer | Sell | 700 | $5.49 | $4K | 23K |
| 2026-09-16 | GRAY MICHAEL | CFO and COO | Sell | 853 | $5.49 | $5K | 28K |
| 2026-09-16 | Deykin Aaron | Chief Medical Officer | Sell | 895 | $5.49 | $5K | 32K |
| 2026-09-16 | Ambrose Allison | General Counsel | Sell | 485 | $5.49 | $3K | 16K |
| 2026-06-16 | Deykin Aaron | Chief Medical Officer | Sell | 895 | $6.10 | $5K | 33K |
| 2026-06-16 | Houghton Adam | Chief Business Officer | Sell | 700 | $6.10 | $4K | 24K |
| 2026-06-16 | Sutherland Everett Rand | Chief Executive Officer | Sell | 2K | $6.10 | $13K | 71K |
| 2026-06-16 | GRAY MICHAEL | CFO and COO | Sell | 853 | $6.10 | $5K | 29K |
| 2026-06-16 | Ambrose Allison | General Counsel | Sell | 477 | $6.10 | $3K | 16K |
| 2026-03-16 | Sutherland Everett Rand | Chief Executive Officer | Sell | 2K | $9.29 | $19K | 73K |
| 2026-03-16 | Houghton Adam | Chief Business Officer | Sell | 699 | $9.29 | $6K | 24K |
| 2026-03-16 | GRAY MICHAEL | CFO and COO | Sell | 852 | $9.29 | $8K | 30K |
| 2026-03-16 | Deykin Aaron | Chief Medical Officer | Sell | 894 | $9.29 | $8K | 33K |
| 2026-03-16 | Ambrose Allison | General Counsel | Sell | 475 | $9.29 | $4K | 17K |
| 2026-01-02 | Sutherland Everett Rand | Chief Executive Officer | Grant | 75K | $0.00 | $0 | 75K |
| 2026-01-02 | Houghton Adam | Chief Business Officer | Grant | 25K | $0.00 | $0 | 25K |
| 2026-01-02 | GRAY MICHAEL | CFO and COO | Grant | 31K | $0.00 | $0 | 31K |
| 2026-01-02 | Deykin Aaron | Chief Medical Officer | Grant | 32K | $0.00 | $0 | 34K |
| 2026-01-02 | Ambrose Allison | General Counsel | Grant | 17K | $0.00 | $0 | 17K |
| 2024-10-15 | Wellington Biomedical Innovation Master Investors (Cayman) II L.P. | TenPercentOwner | Conversion | 895K | price not stated in the filing | not stated | 895K |
| 2024-10-15 | Access Industries Holdings LLC | TenPercentOwner | Conversion | 1.2M | price not stated in the filing | not stated | 5.5M |
| 2024-10-15 | Access Industries Holdings LLC | TenPercentOwner | Conversion | 3.1M | price not stated in the filing | not stated | 4.3M |
| 2024-10-15 | Access Industries Holdings LLC | TenPercentOwner | Buy | 1.2M | $17.00 | $20.0M | 1.2M |
| 2024-10-15 | ORBIMED ADVISORS LLC | Director,TenPercentOwner | Buy | 660K | $17.00 | $11.2M | 4.6M |
| 2024-10-15 | ORBIMED ADVISORS LLC | Director,TenPercentOwner | Conversion | 722K | price not stated in the filing | not stated | 974K |
| 2024-10-15 | ORBIMED ADVISORS LLC | Director,TenPercentOwner | Buy | 165K | $17.00 | $2.8M | 1.1M |
| 2024-10-15 | ORBIMED ADVISORS LLC | Director,TenPercentOwner | Conversion | 2.9M | price not stated in the filing | not stated | 3.9M |
| 2024-10-15 | Chimovits Erez | Director,TenPercentOwner | Buy | 660K | $17.00 | $11.2M | 4.6M |
| 2024-10-15 | Chimovits Erez | Director,TenPercentOwner | Conversion | 2.9M | price not stated in the filing | not stated | 3.9M |
| 2024-10-15 | Chimovits Erez | Director,TenPercentOwner | Buy | 165K | $17.00 | $2.8M | 1.1M |
| 2024-10-15 | Chimovits Erez | Director,TenPercentOwner | Conversion | 722K | price not stated in the filing | not stated | 974K |
Form 4 filings are due within two business days of the trade. Insiders sell for many reasons that say nothing about the company; open-market buys are rarer.
Large holders (13D and 13G)
One row per reporting person with its latest filing, newest first. JSON2 holders report 5% or more of UPB in their latest filing, all on Schedule 13G (passive). The largest reported stake is Norges Bank at 7.7% of the class (4,206,586 shares), filed 2026-08-12 for an event on 2026-06-30.
| Filed | Form | Holder | Shares | Of class | Event |
|---|---|---|---|---|---|
| 2026-10-29 | 13G/Ano. 2 | Decheng Capital Management IV (Cayman), LLCother entity | 2.7M | 4.9% | 2026-09-30 |
| 2026-10-29 | 13G/Ano. 2 | Decheng Capital Global Life Sciences Fund IV, L.P.partnership | 2.7M | 4.9% | 2026-09-30 |
| 2026-10-29 | 13G/Ano. 2 | Xiangmin Cuiindividual | 2.7M | 4.9% | 2026-09-30 |
| 2026-08-12 | 13G/Ano. 1 | Norges Banknon-US institution, other entity | 4.2M | 7.7% | 2026-06-30 |
| 2026-07-30 | 13G | BlackRock, Inc.parent holding company | 2.8M | 5.2% | 2026-06-30 |
| 2026-05-15 | 13G/Ano. 1 | Decheng Capital Global Healthcare Fund (Master), LPpartnership | 0 | 0.0% | 2026-03-31 |
| 2026-05-15 | 13G/Ano. 1 | Decheng Capital Global Healthcare GP, LLCother entity | 0 | 0.0% | 2026-03-31 |
| 2025-11-14 | 13G/Ano. 1 | TCG Crossover GP I, LLCother entity | 2.1M | 3.9% | 2025-09-30 |
| 2025-11-14 | 13G/Ano. 1 | TCG Crossover Fund I, L.P.partnership | 2.1M | 3.9% | 2025-09-30 |
| 2025-11-14 | 13G/Ano. 1 | Chen Yuindividual | 2.1M | 3.9% | 2025-09-30 |
| 2025-11-14 | 13G/Ano. 1 | HBM Healthcare Investments (Cayman) Ltd.corporation | 2.2M | 4.1% | 2025-09-30 |
13F holders
Tracked managers holding UPB at their latest 13F. JSON6 of the 30 tracked managers held UPB at their latest 13F, $23.2M in total at quarter-end prices. Millennium Management is the largest at $7.9M (0.0% of its portfolio) as of 2026-06-30. Over the prior quarter 6 added shares and 0 cut.
| Fund | Quarter | Shares | Value | Of portfolio | Change in shares |
|---|---|---|---|---|---|
| Millennium Management | 2026-06-30 | 1.1M | $7.9M | 0.00% | +206K |
| D. E. Shaw & Co. | 2026-06-30 | 1.0M | $7.2M | 0.00% | +216K |
| AQR Capital Management | 2026-06-30 | 545K | $3.8M | 0.00% | +473K |
| Point72 Asset Management | 2026-06-30 | 453K | $3.1M | 0.00% | +275K |
| Renaissance Technologies | 2026-06-30 | 131K | $909K | 0.00% | +69K |
| Two Sigma Investments | 2026-06-30 | 42K | $293K | 0.00% | new |
Only the 30 tracked managers on the funds hub; a 13F reports long positions in US listed stock at quarter end, 45 days late, and says nothing about shorts or positions sold since.
What this page is
Upstream Bio in the regulatory record
Regulators publish company data in separate files that never sit next to each other: FINRA's twice-monthly short interest, its daily short sale volume, the SEC's fails-to-deliver counts, and each insider's Form 4. A company page puts those series for one ticker on one URL, with planned sales, large holders, 13F holders and financials beside them, so the short position, the daily flow, the settlement fails and what insiders are doing can be read together.
Each section has its own history table, a one-line summary of the latest figures and its own JSON and CSV links, and says when its source last updated.
This page follows Upstream Bio (UPB), SEC CIK 2022626, listed on Nasdaq. The cross-market tables live on the short interest and insider transactions hubs.
Source and updates
- Short interest
- FINRA consolidated short interestSource: FINRA.Twice a month, about eight business days after settlement. Latest 2026-10-15.JSON and CSV
- Daily short volume
- FINRA Reg SHO daily filesSource: FINRA.Every trading day, the morning after FINRA posts it. Latest 2026-11-02.JSON and CSV
- Fails to deliver
- SEC fails-to-deliver dataSource: SEC.Twice a month, a few weeks after the half month ends. Latest 2026-10-13.JSON and CSV
- Large holders
- SEC EDGAR Schedule 13D and 13GSource: SEC.New filings appear shortly after the SEC posts them. A 13D is due within five business days of crossing 5%; a 13G follows the passive schedule. Latest 2026-10-29.JSON and CSV
- 13F holders
- SEC EDGAR Form 13F-HRSource: SEC.Quarterly, filed within 45 days of quarter end; 30 tracked managers. Latest 2026-06-30.JSON and CSV
- Earnings dates
- SEC EDGAR 8-K filings (Item 2.02)Source: SEC.Twice a day. Reported dates come from the company's 8-K filings; the next date is marked as an estimate until the 8-K arrives. Latest 2026-08-11.JSON and CSV
- Insider trades
- SEC EDGAR Form 4Source: SEC.New filings appear shortly after the SEC posts them; they're due two business days after the trade. Latest 2026-09-16.JSON and CSV
- Company record
- EDGAR filing index for CIK 2022626Ticker, name and exchange from the SEC's company list, refreshed weekly.
- Rate limits
- 10 requests a minute without a key, 30 with a free key from a free account.
How to read it
- Read the position against the flow: rising short interest with a high daily short share is new shorting; rising short interest with a normal short share is old shorts holding on.
- Insider buys next to a large short position are rare and stand out; insider sells next to one are common and mean little.
- Fails to deliver matter relative to the float, not in absolute shares; a million failed shares in a mega cap is noise.
Analysis of what the data shows, not advice. XOOMAR does not recommend buying, selling or holding anything.
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Datasets
Frequently Asked Questions
How much of UPB is sold short?
What is UPB's daily short volume?
Does UPB have fails to deliver?
Are UPB insiders buying or selling?
Who owns 5% or more of UPB?
Which tracked 13F managers own UPB?
Data on this page is provided for informational purposes only and is not financial advice. See our editorial policy.