XOOMAR

Spero Therapeutics (SPRO)

Spero Therapeutics on one page: short interest, daily short volume, fails to deliver, 13F holders, earnings dates and insider trades. Listed on Nasdaq, classified by the SEC as pharmaceutical preparations.

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841K

Short interest

settlement 2026-10-15

1.5

Days to cover

+0.5 days vs prior

42.2%

Short share of volume

2026-11-03

1,111

Fails to deliver

settlement 2026-10-13

Thu 12 Nov

Next earnings

estimated date

$0

Insider flow, 90 days

0 buys, 0 sells

As of 2026-11-03.

Short interest

FINRA, twice a month. The newest 48 settlements in the table, 48 in the chart. JSON

As of 15 October 2026, short interest in SPRO is 840,529 shares, down 135,959 shares over the last month. Over the last 48 readings it ranged from 315,715 shares (15 October 2025) to 3,476,335 shares (30 May 2025). At the reported average volume of 558K shares a day that is 1.5 days to cover.

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SettlementShares shortChangeAvg daily volumeDays to cover
2026-10-15840,529+5.8%558,4711.51
2026-09-30794,509-18.6%1,144,0971.00
2026-09-15976,488-19.3%319,4583.06
2026-08-311,210,417-16.3%409,8132.95
2026-08-141,445,879-4.5%760,5111.90
2026-07-311,513,354-28.4%2,524,6911.00
2026-07-152,113,935-26.2%1,649,6271.28
2026-06-302,864,850+56.4%2,752,0491.04
2026-06-151,831,713+7.3%813,3752.25
2026-05-291,706,545+3.6%868,8681.96
2026-05-151,647,297+39.6%630,4692.61
2026-04-301,179,702+59.9%385,4213.06
2026-04-15737,720+21.9%531,2211.39
2026-03-31605,311+12.6%325,5761.86
2026-03-13537,411-6.4%312,9391.72
2026-02-27574,027-19.8%270,5672.12
2026-02-13715,694-24.0%426,9551.68
2026-01-30941,659-9.4%234,7104.01
2026-01-151,039,613+9.8%234,7374.43
2025-12-31946,767-10.3%245,7363.85
2025-12-151,056,013+27.9%300,6213.51
2025-11-28825,698+34.1%385,6532.14
2025-11-14615,735+29.3%584,1421.05
2025-10-31476,137+50.8%1,550,7851.00
2025-10-15315,715-42.5%535,3761.00
2025-09-30549,473+19.8%266,1052.06
2025-09-15458,620-9.0%347,3631.32
2025-08-29503,998-45.6%371,9991.35
2025-08-15927,158-32.8%1,013,6361.00
2025-07-311,379,953+13.4%614,3812.25
2025-07-151,217,101-28.3%1,000,7301.22
2025-06-301,697,497+5.3%1,373,3511.24
2025-06-131,612,678-53.6%2,786,5021.00
2025-05-303,476,335+446.0%21,430,4811.00
2025-05-15636,730-1.3%113,1265.63
2025-04-30645,163-19.5%78,3778.23
2025-04-15801,304+60.9%248,8513.22
2025-03-31498,066+13.9%144,3953.45
2025-03-14437,248+3.0%94,9774.60
2025-02-28424,739-1.1%94,4044.50
2025-02-14429,588+14.0%333,4711.29
2025-01-31376,788+6.4%188,4242.00
2025-01-15354,105-14.2%225,8571.57
2024-12-31412,644-8.6%309,0531.34
2024-12-13451,216-8.6%160,6362.81
2024-11-29493,832-9.7%265,8881.86
2024-11-15546,831-12.5%319,5561.71
2024-10-31625,191+61.5%417,6431.50

Daily short volume

FINRA Reg SHO, the last 30 sessions. JSON

As of 3 November 2026, the short share of SPRO volume is 42.2%, up 6.3 points over the last five sessions. Over the last 30 readings it ranged from 14.2% (21 October 2026) to 50.5% (30 October 2026). The latest reading is 9.1 points above the 30-session average of 33.2%, on 139K shares reported.

DateShort volumeTotal volumeShort shareExempt
2026-11-0359K139K42.2%500
2026-11-0284K275K30.6%0
2026-10-3081K161K50.5%0
2026-10-2942K104K40.6%0
2026-10-2834K143K23.6%0
2026-10-2795K265K35.9%0
2026-10-26134K302K44.2%0
2026-10-2383K166K50.0%0
2026-10-2243K130K33.0%0
2026-10-2115K104K14.2%0
2026-10-2089K358K24.9%0
2026-10-1956K126K44.9%0
2026-10-1638K185K20.6%0
2026-10-1553K141K37.6%0
2026-10-14100K274K36.3%50
2026-10-1345K130K34.4%0
2026-10-1253K185K28.6%0
2026-10-0965K219K29.5%0
2026-10-0844K185K23.9%0
2026-10-0720K133K15.0%0
2026-10-06100K204K48.9%0
2026-10-05107K229K46.7%319
2026-10-0294K285K32.9%500
2026-10-01250K513K48.6%0
2026-09-3027K85K31.6%0
2026-09-2965K173K37.4%0
2026-09-2833K132K25.3%0
2026-09-2527K166K16.2%0
2026-09-2454K225K24.0%0
2026-09-23155K690K22.4%0

Fails to deliver

SEC, the last 30 settlement dates with a fail. JSON

As of 13 October 2026, the fails-to-deliver balance in SPRO is 1,111 shares, down 48,889 shares over the last settlement date. Over the last 30 readings it ranged from 5 shares (29 July 2026) to 55,493 shares (20 July 2026). The latest reading sits at the bottom of that range.

SettlementShares failedPriceValue
2026-10-131,111$1.18$1K
2026-10-0250,000$1.26$63K
2026-08-2515,213$1.22$19K
2026-08-2017$1.23$21
2026-08-12742$1.23$913
2026-08-1128$1.23$34
2026-08-1026,872$1.26$34K
2026-08-0612,711$1.26$16K
2026-08-0438,252$1.15$44K
2026-08-0334$1.17$40
2026-07-295$1.20$6
2026-07-245,270$1.16$6K
2026-07-2055,493$1.58$88K
2026-07-17409$1.57$642
2026-07-1410,521$2.18$23K
2026-07-1315,259$2.10$32K
2026-07-1010,000$2.12$21K
2026-07-01171$2.21$378
2026-06-3047,602$2.26$108K
2026-06-29730$2.26$2K
2026-06-241,011$2.15$2K
2026-06-229,572$2.28$22K
2026-06-183,755$2.11$8K
2026-06-1720,293$2.77$56K
2026-06-165,631$2.91$16K
2026-06-1523,494$2.85$67K
2026-06-125,678$2.70$15K
2026-06-1115,911$2.54$40K
2026-06-0811,224$2.82$32K
2026-05-2916,734$2.90$49K

Insider trades

SEC Form 4, newest first. JSON

No open-market insider trades were reported for SPRO in the last 90 days. The most recent filings are listed below. Latest filing: Zack Debra (Chief Medical Officer) on 2026-08-03.

DateInsiderTitleTypeSharesPriceValueOwned after
2026-08-03Zack DebraChief Medical OfficerGrant162K$0.00$0162K
2026-06-23Pottage John C JrDirectorGrant10K$0.00$085K
2026-06-23Jackson Scott ThomasDirectorGrant10K$0.00$085K
2026-06-23THOMAS FRANK EDirectorGrant10K$0.00$085K
2026-06-23VINK PATRICK V.J.J.DirectorGrant10K$0.00$085K
2026-06-23Smith CynthiaDirectorGrant10K$0.00$085K
2026-06-23Tregoning KathleenDirectorGrant10K$0.00$085K
2026-06-23Deshpande MilindDirectorGrant10K$0.00$0101K
2026-05-04Rajavelu EstherSee RemarksSell25K$2.51$63K987K
2026-02-06Rajavelu EstherSee RemarksSell51K$2.36$120K1.0M
2026-02-06Rajavelu EstherSee RemarksSell37K$2.36$88K1.1M
2026-02-06Keutzer TimothyChief Operating OfficerSell19K$2.36$44K743K
2026-02-04Keutzer TimothyChief Operating OfficerSell3K$2.24$8K761K
2026-02-03Keutzer TimothyChief Operating OfficerSell24K$2.14$52K765K
2026-02-02Rajavelu EstherSee RemarksSell18K$2.20$41K1.1M
2026-02-02Rajavelu EstherSee RemarksGrant249K$0.00$01.1M
2026-02-02Keutzer TimothyChief Operating OfficerSell19K$2.20$42K789K
2026-02-02Keutzer TimothyChief Operating OfficerGrant68K$0.00$0808K
2025-11-07Rajavelu EstherSee RemarksSell40K$2.37$95K869K
2025-08-28Mahadevia AnkitDirectorSell7K$1.97$13K703K
2025-08-28Keutzer TimothyChief Operating OfficerSell2K$1.97$3K740K
2025-06-12VINK PATRICK V.J.J.DirectorGrant20K$0.00$075K
2025-06-12THOMAS FRANK EDirectorGrant20K$0.00$075K
2025-06-12Tregoning KathleenDirectorGrant20K$0.00$075K
2025-06-12Smith CynthiaDirectorGrant20K$0.00$075K
2025-06-12Pottage John C JrDirectorGrant20K$0.00$075K
2025-06-12Mahadevia AnkitDirectorGrant20K$0.00$0710K
2025-06-12Jackson Scott ThomasDirectorGrant20K$0.00$075K
2025-06-12Deshpande MilindDirectorGrant20K$0.00$091K
2025-05-02Rajavelu EstherSee RemarksGrant185K$0.00$0910K
2025-02-05Mahadevia AnkitDirectorSell55K$0.78$43K690K
2025-02-05Mahadevia AnkitDirectorSell14K$0.78$11K745K
2025-02-05Shukla SathCEO & PresidentSell6K$0.78$5K1.9M
2025-02-05Shukla SathCEO & PresidentSell43K$0.78$33K1.8M
2025-02-05Shukla SathCEO & PresidentSell106K$0.78$83K1.7M
2025-02-05Rajavelu EstherCFO & CBOSell21K$0.78$16K725K
2025-02-05Keutzer TimothyChief Operating OfficerSell4K$0.78$3K794K
2025-02-05Keutzer TimothyChief Operating OfficerSell28K$0.78$22K766K
2025-02-05Keutzer TimothyChief Operating OfficerSell25K$0.78$19K741K
2025-02-03Shukla SathCEO & PresidentGrant751K$0.00$01.9M
2025-02-03Rajavelu EstherCFO & CBOGrant266K$0.00$0645K
2025-02-03Rajavelu EstherCFO & CBOGrant100K$0.00$0745K
2025-02-03Keutzer TimothyChief Operating OfficerGrant266K$0.00$0798K
2024-11-08Rajavelu EstherCFO & CBOSell17K$1.30$22K379K
2024-11-07Rajavelu EstherCFO & CBOSell23K$1.31$31K397K
2024-08-27Shukla SathCEO & PresidentSell3K$1.35$4K1.1M
2024-08-27Keutzer TimothyChief Operating OfficerSell2K$1.35$3K532K
2024-08-27Mahadevia AnkitDirectorSell6K$1.35$8K759K
2024-08-05Shukla SathCEO and PresidentSell18K$1.31$23K1.1M
2024-08-02Shukla SathCEO and PresidentSell15K$1.32$20K1.2M
2024-05-29Pottage John C JrDirectorGrant20K$0.00$055K
2024-05-29THOMAS FRANK EDirectorGrant20K$0.00$055K
2024-05-29Smith CynthiaDirectorGrant20K$0.00$055K
2024-05-29VINK PATRICK V.J.J.DirectorGrant20K$0.00$055K
2024-05-29Tregoning KathleenDirectorGrant20K$0.00$055K
2024-05-29Mahadevia AnkitDirectorGrant20K$0.00$0765K
2024-05-29Jackson Scott ThomasDirectorGrant20K$0.00$055K
2024-05-29Deshpande MilindDirectorGrant20K$0.00$071K
2024-02-05Shukla SathCEO and PresidentSell45K$1.45$65K1.2M
2024-02-02Shukla SathCEO and PresidentSell31K$1.37$42K1.2M
2024-02-02HAMED KAMALChief Medical OfficerSell28K$1.37$38K788K
2024-02-02JOSEPH TAMARA LChief Legal OfficerSell31K$1.37$42K532K
2024-02-02Mahadevia AnkitDirectorSell64K$1.37$87K745K
2024-02-02Keutzer TimothyChief Operating OfficerSell31K$1.36$42K534K
2024-02-01Shukla SathCEO and PresidentGrant680K$0.00$01.3M
2024-02-01Rajavelu EstherSee RemarksGrant120K$0.00$0420K
2024-02-01HAMED KAMALChief Medical OfficerGrant240K$0.00$0816K
2024-02-01JOSEPH TAMARA LChief Legal OfficerGrant240K$0.00$0563K
2024-02-01Keutzer TimothyChief Operating OfficerGrant240K$0.00$0565K
2023-11-13Rajavelu EstherSee RemarksGrant300K$0.00$0300K
2023-10-05Mahadevia AnkitDirectorGrant20K$0.00$0809K
2023-10-05Jackson Scott ThomasDirectorGrant20K$0.00$035K
2023-10-05VINK PATRICK V.J.J.DirectorGrant20K$0.00$035K
2023-10-05Tregoning KathleenDirectorGrant20K$0.00$035K
2023-10-05Deshpande MilindDirectorGrant20K$0.00$051K
2023-10-05THOMAS FRANK EDirectorGrant20K$0.00$035K
2023-10-05Smith CynthiaDirectorGrant20K$0.00$035K
2023-10-05Pottage John C JrDirectorGrant20K$0.00$035K
2023-09-13HAMED KAMALChief Medical OfficerSell39K$1.27$50K576K
2023-08-29Shukla SathCEO and PresidentSell4K$1.30$5K573K
2023-08-28Shukla SathCEO and PresidentSell2K$1.26$2K577K
2023-08-28Mahadevia AnkitDirectorSell9K$1.26$11K789K
2023-08-28JOSEPH TAMARA LChief Legal OfficerSell2K$1.26$2K323K
2023-08-28Keutzer TimothyChief Development OfficerSell2K$1.26$2K325K
2023-08-01Shukla SathCEO and PresidentGrant266K$0.00$0579K
2023-06-12HAMED KAMALChief Medical OfficerGrant140K$0.00$0616K
2023-02-03Mahadevia AnkitCEO and PresidentSell12K$1.81$22K798K
2023-02-02Shukla SathChief Financial OfficerSell10K$1.83$17K313K
2023-02-02JOSEPH TAMARA LChief Legal OfficerSell3K$1.86$6K325K
2023-02-02Keutzer TimothyChief Operating OfficerSell3K$1.86$6K327K
2023-02-01Mahadevia AnkitCEO and PresidentGrant532K$0.00$0810K
2023-02-01HAMED KAMALChief Medical OfficerGrant266K$0.00$0476K
2023-02-01Shukla SathChief Financial OfficerGrant266K$0.00$0322K
2023-02-01JOSEPH TAMARA LChief Legal OfficerGrant266K$0.00$0328K
2023-02-01Keutzer TimothyChief Operating OfficerGrant266K$0.00$0331K
2022-09-22Aquilo Capital Management, LLCTenPercentOwnerSell1.3M$2.25$3.0M4.0M
2022-09-22Aquilo Capital Management, LLCTenPercentOwnerSell566K$2.25$1.3M3.4M
2022-09-15VINK PATRICK V.J.J.DirectorGrant15K$0.00$015K
2022-09-15Tregoning KathleenDirectorGrant15K$0.00$015K
2022-09-15THOMAS FRANK EDirectorGrant15K$0.00$015K

Form 4 filings are due within two business days of the trade. Insiders sell for many reasons that say nothing about the company; open-market buys are rarer.

13F holders

Tracked managers holding SPRO at their latest 13F. JSON

4 of the 30 tracked managers held SPRO at their latest 13F, $3.2M in total at quarter-end prices. Renaissance Technologies is the largest at $2.1M (0.0% of its portfolio) as of 2026-06-30. Over the prior quarter 2 added shares and 2 cut.

FundQuarterSharesValueOf portfolioChange in shares
Renaissance Technologies2026-06-30948K$2.1M0.00%-241K
Two Sigma Investments2026-06-30383K$846K0.00%-503K
Point72 Asset Management2026-06-30104K$231K0.00%+45K
Millennium Management2026-06-3019K$43K0.00%new

Only the 30 tracked managers on the funds hub; a 13F reports long positions in US listed stock at quarter end, 45 days late, and says nothing about shorts or positions sold since.

What this page is

Spero Therapeutics in the regulatory record

Regulators publish company data in separate files that never sit next to each other: FINRA's twice-monthly short interest, its daily short sale volume, the SEC's fails-to-deliver counts, and each insider's Form 4. A company page puts those series for one ticker on one URL, with planned sales, large holders, 13F holders and financials beside them, so the short position, the daily flow, the settlement fails and what insiders are doing can be read together.

Each section has its own history table, a one-line summary of the latest figures and its own JSON and CSV links, and says when its source last updated.

This page follows Spero Therapeutics (SPRO), SEC CIK 1701108, listed on Nasdaq, classified by the SEC as pharmaceutical preparations. The cross-market tables live on the short interest and insider transactions hubs.

Source and updates

Short interest
FINRA consolidated short interestSource: FINRA.Twice a month, about eight business days after settlement. Latest 2026-10-15.JSON and CSV
Daily short volume
FINRA Reg SHO daily filesSource: FINRA.Every trading day, the morning after FINRA posts it. Latest 2026-11-03.JSON and CSV
Fails to deliver
SEC fails-to-deliver dataSource: SEC.Twice a month, a few weeks after the half month ends. Latest 2026-10-13.JSON and CSV
13F holders
SEC EDGAR Form 13F-HRSource: SEC.Quarterly, filed within 45 days of quarter end; 30 tracked managers. Latest 2026-06-30.JSON and CSV
Earnings dates
SEC EDGAR 8-K filings (Item 2.02)Source: SEC.Twice a day. Reported dates come from the company's 8-K filings; the next date is marked as an estimate until the 8-K arrives. Latest 2026-05-13.JSON and CSV
Insider trades
SEC EDGAR Form 4Source: SEC.New filings appear shortly after the SEC posts them; they're due two business days after the trade. Latest 2026-08-03.JSON and CSV
Company record
EDGAR filing index for CIK 1701108Ticker, name and exchange from the SEC's company list, refreshed weekly.
Rate limits
10 requests a minute without a key, 30 with a free key from a free account.

How to read it

  • Read the position against the flow: rising short interest with a high daily short share is new shorting; rising short interest with a normal short share is old shorts holding on.
  • Insider buys next to a large short position are rare and stand out; insider sells next to one are common and mean little.
  • Fails to deliver matter relative to the float, not in absolute shares; a million failed shares in a mega cap is noise.

Analysis of what the data shows, not advice. XOOMAR does not recommend buying, selling or holding anything.

Datasets

Frequently Asked Questions

How much of SPRO is sold short?
840,529 shares were held short at the 2026-10-15 settlement, 1.5 days of average volume. FINRA publishes the next count about eight business days after the 15th and the last business day of the month.
What is SPRO's daily short volume?
On 2026-11-03, 58,681 of the 138,951 SPRO shares reported to FINRA were sold short, 42.2% of the day's reported volume. Short volume is a flow for one day, not a position.
Does SPRO have fails to deliver?
The SEC's latest file shows 1,111 SPRO shares failed to deliver at settlement 2026-10-13. Fails are reported per settlement date and published twice a month with a lag.
Are SPRO insiders buying or selling?
No open-market insider trades were reported for SPRO in the last 90 days. The most recent filings are listed below. Latest filing: Zack Debra (Chief Medical Officer) on 2026-08-03.
Which tracked 13F managers own SPRO?
4 of the 30 tracked 13F managers held SPRO shares at their latest filing, $3.2M in all. The largest: Renaissance Technologies (948K shares, $2.1M), Two Sigma Investments (383K shares, $846K), Steve Cohen's Point72 Asset Management (104K shares, $231K), Izzy Englander's Millennium Management (19K shares, $43K).

Data on this page is provided for informational purposes only and is not financial advice. See our editorial policy.