XOOMAR

Xilio Therapeutics (XLO)

Xilio Therapeutics on one page: short interest, daily short volume, fails to deliver, large holders, 13F holders, earnings dates and insider trades. Listed on Nasdaq, classified by the SEC as pharmaceutical preparations.

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400K

Short interest

settlement 2026-10-15

41.2

Days to cover

-3.4 days vs prior

52.4%

Short share of volume

2026-11-02

46

Fails to deliver

settlement 2026-10-13

Thu 12 Nov

Next earnings

estimated date

$0

Insider flow, 90 days

0 buys, 0 sells

As of 2026-11-02.

Short interest

FINRA, twice a month. The newest 48 settlements in the table, 48 in the chart. JSON

As of 15 October 2026, short interest in XLO is 400,316 shares, down 12,647 shares over the last month. Over the last 48 readings it ranged from 41,958 shares (15 November 2024) to 6,913,181 shares (14 November 2025). The latest reading sits at the bottom of that range. At the reported average volume of 10K shares a day that is 41.2 days to cover.

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SettlementShares shortChangeAvg daily volumeDays to cover
2026-10-15400,316-2.4%9,72741.16
2026-09-30410,050-0.7%9,21044.52
2026-09-15412,963-1.3%11,05537.36
2026-08-31418,277-0.9%10,70539.07
2026-08-14421,921-0.9%13,34031.63
2026-07-31425,882+58.8%34,68012.28
2026-07-15268,180+53.6%59,3494.52
2026-06-30174,619+0.7%47,8683.65
2026-06-15173,470+5.0%24,4587.09
2026-05-29165,274-3.6%30,4655.43
2026-05-15171,370+5.2%95,0331.80
2026-04-30162,958-6.5%32,9724.94
2026-04-15174,319-4.5%29,4315.92
2026-03-31182,492-91.8%58,2983.13
2026-03-132,231,716+5.6%480,8084.64
2026-02-272,113,748-1.9%312,2266.77
2026-02-132,155,562+0.8%602,3033.58
2026-01-302,139,403+2.4%516,3344.14
2026-01-152,088,847-3.7%358,0625.83
2025-12-312,168,608-29.8%269,7078.04
2025-12-153,088,368-53.7%737,1844.19
2025-11-286,675,820-3.4%372,25417.93
2025-11-146,913,181+12.3%1,166,8475.92
2025-10-316,156,308+17.2%717,8168.58
2025-10-155,251,586+1.7%422,78812.42
2025-09-305,162,356+4.8%386,95013.34
2025-09-154,923,762+14.5%1,458,9193.37
2025-08-294,300,761-0.2%396,20310.85
2025-08-154,308,767+12.7%452,4849.52
2025-07-313,821,839+14.5%369,46010.34
2025-07-153,338,281+0.6%312,27510.69
2025-06-303,317,060+26.4%468,3457.08
2025-06-132,624,728+231.6%1,283,7252.04
2025-05-30791,482-35.1%608,4211.30
2025-05-151,219,174+247.2%4,687,1081.00
2025-04-30351,157-37.5%201,6651.74
2025-04-15562,279-12.8%205,5012.74
2025-03-31644,535+12.0%257,7052.50
2025-03-14575,448-17.2%664,5761.00
2025-02-28694,611-61.6%2,467,8291.00
2025-02-141,810,353+809.5%19,533,9551.00
2025-01-31199,049-6.6%488,1461.00
2025-01-15213,071-44.5%362,7021.00
2024-12-31384,094+221.6%1,523,7951.00
2024-12-13119,440-31.9%81,9061.46
2024-11-29175,269+317.7%154,5861.13
2024-11-1541,958-89.4%362,6611.00
2024-10-31396,085+278.1%476,7721.00

Daily short volume

FINRA Reg SHO, the last 30 sessions. JSON

As of 2 November 2026, the short share of XLO volume is 52.4%, up 16.0 points over the last five sessions. Over the last 30 readings it ranged from 4.6% (6 October 2026) to 78.0% (23 September 2026). The latest reading is 14.9 points above the 30-session average of 37.5%, on 4K shares reported.

DateShort volumeTotal volumeShort shareExempt
2026-11-022K4K52.4%0
2026-10-301K4K30.8%0
2026-10-2910987712.4%0
2026-10-284K10K37.8%0
2026-10-276K12K47.5%0
2026-10-266K17K36.4%0
2026-10-233K8K37.0%200
2026-10-221K3K30.9%0
2026-10-216K14K46.8%0
2026-10-202K5K39.2%0
2026-10-191K5K19.8%0
2026-10-165913K16.9%0
2026-10-152K5K35.1%0
2026-10-142K3K52.9%0
2026-10-131K5K28.5%0
2026-10-129433K27.7%0
2026-10-095813K18.4%0
2026-10-081K3K32.2%0
2026-10-072416614.5%0
2026-10-061042K4.6%0
2026-10-051K2K67.9%0
2026-10-021K2K64.3%0
2026-10-015992K28.5%0
2026-09-30516777.5%0
2026-09-295891K54.3%0
2026-09-286912K32.7%0
2026-09-251K2K75.8%0
2026-09-243K6K46.7%500
2026-09-2313116878.0%0
2026-09-221K3K46.8%0

Fails to deliver

SEC, the last 30 settlement dates with a fail. JSON

As of 13 October 2026, the fails-to-deliver balance in XLO is 46 shares, up 44 shares over the last settlement date. Over the last 30 readings it ranged from 2 shares (9 October 2026) to 3,621 shares (1 October 2026). The latest reading sits at the bottom of that range.

SettlementShares failedPriceValue
2026-10-1346$9.15$421
2026-10-092$9.01$18
2026-10-0761$8.97$547
2026-10-05961$8.96$9K
2026-10-013,621$9.05$33K
2026-09-30311$9.19$3K
2026-09-29291$9.05$3K
2026-09-28269$9.04$2K
2026-09-25460$9.00$4K
2026-09-212,087$9.13$19K
2026-09-182,609$9.04$24K
2026-09-171,695$8.98$15K
2026-09-162,368$9.03$21K
2026-09-15581$8.93$5K
2026-09-14115$8.93$1K
2026-09-11258$8.93$2K
2026-09-0958$8.91$517
2026-09-08161$9.00$1K
2026-09-01131$8.95$1K
2026-08-21881$9.23$8K
2026-08-20742$9.41$7K
2026-08-19582$9.50$6K
2026-08-18198$9.49$2K
2026-08-172,032$9.17$19K
2026-08-14501$9.01$5K
2026-08-131,588$9.05$14K
2026-08-1015$9.11$137
2026-08-071,203$9.27$11K
2026-08-061,445$9.11$13K
2026-08-052,601$9.09$24K

Insider trades

SEC Form 4, newest first. JSON

No open-market insider trades were reported for XLO in the last 90 days. The most recent filings are listed below. Latest filing: Shannon James Samuel (Director) on 2026-03-26.

DateInsiderTitleTypeSharesPriceValueOwned after
2026-03-26Shannon James SamuelDirectorBuy5K$8.79$44K10K
2026-01-02Frankenfield Christopher JamesChief Financial OfficerSell7K$0.64$4K25K
2026-01-02Brennan Kevin M.SVP, FINANCE AND ACCOUNTINGSell2K$0.64$1K6K
2026-01-01Russo RenePRESIDENT AND CEOExercise or conversion44Kprice not stated in the filingnot stated325K
2026-01-01Frankenfield Christopher JamesChief Financial OfficerExercise or conversion19Kprice not stated in the filingnot stated32K
2026-01-01Brennan Kevin M.SVP, FINANCE AND ACCOUNTINGExercise or conversion5Kprice not stated in the filingnot stated8K
2026-01-01Luptakova KatarinaCHIEF MEDICAL OFFICERExercise or conversion17Kprice not stated in the filingnot stated33K
2025-06-17Shannon James SamuelDirectorBuy25K$0.69$17K70K
2025-06-16Shannon James SamuelDirectorBuy45K$0.69$31K45K
2025-06-16Russo RenePRESIDENT AND CEOBuy36K$0.68$25K281K
2025-01-02Brennan Kevin M.SVP, FINANCE AND ACCOUNTINGSell2K$0.98$2K3K
2025-01-02Frankenfield Christopher JamesChief Financial OfficerSell7K$0.98$7K12K
2025-01-01Brennan Kevin M.SVP, FINANCE AND ACCOUNTINGExercise or conversion5Kprice not stated in the filingnot stated5K
2025-01-01Russo RenePRESIDENT AND CEOExercise or conversion44Kprice not stated in the filingnot stated245K
2025-01-01Luptakova KatarinaCHIEF MEDICAL OFFICERExercise or conversion17Kprice not stated in the filingnot stated17K
2025-01-01Frankenfield Christopher JamesChief Financial OfficerExercise or conversion19Kprice not stated in the filingnot stated19K
2024-12-18GILEAD SCIENCES, INC.TenPercentOwnerBuy1.8M$1.04$1.8M9.1M
2024-04-02GILEAD SCIENCES, INC.TenPercentOwnerBuy485K$0.76$369K7.3M
2024-02-08Atlas Venture Fund XI, L.P.TenPercentOwnerSell733$0.64$4692.0M
2024-02-08Atlas Venture Fund XI, L.P.TenPercentOwnerSell267$0.64$171735K
2024-01-12Atlas Venture Associates Opportunity I, L.P.TenPercentOwnerSell2K$0.83$1K2.0M
2024-01-12Atlas Venture Associates Opportunity I, L.P.TenPercentOwnerSell560$0.83$465735K
2024-01-11Atlas Venture Associates Opportunity I, L.P.TenPercentOwnerSell569$0.87$495735K
2024-01-11Atlas Venture Associates Opportunity I, L.P.TenPercentOwnerSell2K$0.87$1K2.0M
2021-12-10BCIP Life Sciences Associates, LPTenPercentOwnerBuy22K$9.56$209K2.8M
2021-12-10BCIP Life Sciences Associates, LPTenPercentOwnerBuy3K$10.24$33K2.8M
2021-12-09BCIP Life Sciences Associates, LPTenPercentOwnerBuy4K$9.84$39K2.8M
2021-12-08BCIP Life Sciences Associates, LPTenPercentOwnerBuy13K$9.62$129K2.8M
2021-10-26Alexandria Venture Investments, LLCTenPercentOwnerConversion166Kprice not stated in the filingnot stated166K
2021-10-26Atlas Venture Opportunity Fund I, L.P.TenPercentOwnerBuy188K$16.00$3.0M736K
2021-10-26Atlas Venture Opportunity Fund I, L.P.TenPercentOwnerConversion1.4Mprice not stated in the filingnot stated1.4M
2021-10-26Atlas Venture Opportunity Fund I, L.P.TenPercentOwnerConversion624Kprice not stated in the filingnot stated2.0M
2021-10-26Atlas Venture Opportunity Fund I, L.P.TenPercentOwnerConversion548Kprice not stated in the filingnot stated548K
2021-10-26BAY CITY CAPITAL LLCTenPercentOwnerBuy313K$16.00$5.0M1.1M
2021-10-26BAY CITY CAPITAL LLCTenPercentOwnerConversion666Kprice not stated in the filingnot stated666K
2021-10-26BAY CITY CAPITAL LLCTenPercentOwnerConversion151Kprice not stated in the filingnot stated817K
2021-10-26Merck KGaATenPercentOwnerConversion416Kprice not stated in the filingnot stated416K
2021-10-26Merck KGaATenPercentOwnerConversion265Kprice not stated in the filingnot stated681K
2021-10-26Rock Springs Capital Master Fund LPTenPercentOwnerConversion756Kprice not stated in the filingnot stated756K
2021-10-26Rock Springs Capital Master Fund LPTenPercentOwnerConversion151Kprice not stated in the filingnot stated151K
2021-10-26Rock Springs Capital Master Fund LPTenPercentOwnerBuy500K$16.00$8.0M1.3M
2021-10-26RiverVest Venture Fund IV, L.P.TenPercentOwnerBuy250K$16.00$4.0M1.4M
2021-10-26RiverVest Venture Fund IV, L.P.TenPercentOwnerConversion832Kprice not stated in the filingnot stated832K
2021-10-26RiverVest Venture Fund IV, L.P.TenPercentOwnerConversion359Kprice not stated in the filingnot stated1.2M
2021-10-26Takeda Ventures, Inc.TenPercentOwnerConversion1.5Mprice not stated in the filingnot stated1.5M
2021-10-26SV7 (IMF) GP LLPTenPercentOwnerConversion303Kprice not stated in the filingnot stated1.3M
2021-10-26SV7 (IMF) GP LLPTenPercentOwnerConversion999Kprice not stated in the filingnot stated999K
2021-10-26FMR LLCOtherConversion789Kprice not stated in the filingnot stated816K
2021-10-26FMR LLCOtherConversion372Kprice not stated in the filingnot stated372K
2021-10-26FMR LLCOtherConversion29Kprice not stated in the filingnot stated1.5M
2021-10-26FMR LLCOtherConversion686Kprice not stated in the filingnot stated1.5M
2021-10-26FMR LLCOtherConversion4Kprice not stated in the filingnot stated4K
2021-10-26FIL LtdOtherConversion219Kprice not stated in the filingnot stated219K
2021-10-26Deerfield Mgmt L.P.TenPercentOwnerOtherConversion756Kprice not stated in the filingnot stated756K
2021-10-26Deerfield Mgmt L.P.TenPercentOwnerOtherBuy388K$16.00$6.2M1.1M
2021-10-26SV7 Impact Medicine Fund LPTenPercentOwnerBuy313K$16.00$5.0M1.6M
2021-10-26SV7 Impact Medicine Fund LPTenPercentOwnerConversion303Kprice not stated in the filingnot stated1.3M
2021-10-26SV7 Impact Medicine Fund LPTenPercentOwnerConversion999Kprice not stated in the filingnot stated999K

Form 4 filings are due within two business days of the trade. Insiders sell for many reasons that say nothing about the company; open-market buys are rarer.

Large holders (13D and 13G)

One row per reporting person with its latest filing, newest first. JSON

17 holders report 5% or more of XLO in their latest filing, all on Schedule 13G (passive). The largest reported stake is GILEAD SCIENCES, INC. at 19.9% of the class (14,517,678 shares), filed 2026-02-12 for an event on 2025-12-31.

FiledFormHolderSharesOf classEvent
2026-08-1413G/Ano. 2StemPoint Capital Management GP LLCother entity629K9.5%2026-06-30
2026-08-1413G/Ano. 2StemPoint Capital LPinvestment adviser, partnership629K9.5%2026-06-30
2026-08-1413G/Ano. 2Michelle Rossparent holding company, individual629K9.5%2026-06-30
2026-05-1513G/Ano. 4BCLS II Equity Opportunities, LPpartnership664K10.0%2026-03-31
2026-05-1513G/Ano. 4Bain Capital Life Sciences Fund II, L.P.partnership00.0%2026-03-31
2026-05-1513G/Ano. 4BCIP Life Sciences Associates, LPpartnership00.0%2026-03-31
2026-05-1513GORBIMED ADVISORS LLCinvestment adviser642K10.0%2026-03-31
2026-05-1513GOrbiMed Capital GP X LLCother entity482K7.5%2026-03-31
2026-05-1513G/Ano. 2Point72 Asset Management, L.P.partnership00.0%2026-03-31
2026-05-1513G/Ano. 2Point72 Capital Advisors, Inc.corporation00.0%2026-03-31
2026-05-1513G/Ano. 2Steven A. Cohenindividual00.0%2026-03-31
2026-05-1513GSirenia Capital Management LPinvestment adviser, partnership1.1M9.9%2026-03-31
2026-05-1513GAlex Silversteinparent holding company, individual1.1M9.9%2026-03-31
2026-02-1713G/Ano. 3BCLS II Investco, LPpartnership00.0%2025-12-31
2026-02-1313G/Ano. 2FHMLSP, L.P.partnership4.7M6.7%2025-12-31
2026-02-1313G/Ano. 2Frazier Life Sciences Public Fund, L.P.partnership4.7M6.7%2025-12-31
2026-02-1313G/Ano. 2FHMLSP, L.L.C.other entity4.7M6.7%2025-12-31
2026-02-1313G/Ano. 2FHMLS XII, L.L.C.other entity693K1.0%2025-12-31
2026-02-1313G/Ano. 2FHMLS XII, L.P.partnership693K1.0%2025-12-31
2026-02-1313G/Ano. 2Frazier Life Sciences XII, L.P.partnership693K1.0%2025-12-31
2026-02-1313G/Ano. 2FHMLS XI, L.P.partnership397K0.6%2025-12-31
2026-02-1313G/Ano. 2Frazier Life Sciences XI, L.P.partnership397K0.6%2025-12-31
2026-02-1313G/Ano. 2FHMLS XI, L.L.C.other entity397K0.6%2025-12-31
2026-02-1313G/Ano. 2FHMLS X, L.L.C.other entity149K0.2%2025-12-31
2026-02-1313G/Ano. 2FHMLS X, L.P.partnership149K0.2%2025-12-31
2026-02-1313G/Ano. 2Frazier Life Sciences X, L.P.partnership149K0.2%2025-12-31
2026-02-1313G/Ano. 2Patrick J. Heronindividual149K0.2%2025-12-31
2026-02-1313G/Ano. 2James N. Topperindividual149K0.2%2025-12-31
2026-02-1213G/Ano. 3GILEAD SCIENCES, INC.corporation14.5M19.9%2025-12-31
2025-12-1113GCoastlands Capital LPinvestment adviser, partnership5.3M10.0%2025-12-04
2025-12-1113GCoastlands Capital Partners LPpartnership5.3M10.0%2025-12-04
2025-12-1113GCoastlands Capital GP LLCother entity5.3M10.0%2025-12-04
2025-12-1113GCoastlands Capital LLCparent holding company, other entity5.3M10.0%2025-12-04
2025-12-1113GMatthew D. Perryparent holding company, individual5.3M10.0%2025-12-04

13F holders

Tracked managers holding XLO at their latest 13F. JSON

3 of the 30 tracked managers held XLO at their latest 13F, $1.0M in total at quarter-end prices. Renaissance Technologies is the largest at $615K (0.0% of its portfolio) as of 2026-06-30. Over the prior quarter 3 added shares and 0 cut.

FundQuarterSharesValueOf portfolioChange in shares
Renaissance Technologies2026-06-3064K$615K0.00%+15K
Citadel Advisors2026-06-3026K$249K0.00%new
Two Sigma Investments2026-06-3015K$139K0.00%new

Only the 30 tracked managers on the funds hub; a 13F reports long positions in US listed stock at quarter end, 45 days late, and says nothing about shorts or positions sold since.

What this page is

Xilio Therapeutics in the regulatory record

Regulators publish company data in separate files that never sit next to each other: FINRA's twice-monthly short interest, its daily short sale volume, the SEC's fails-to-deliver counts, and each insider's Form 4. A company page puts those series for one ticker on one URL, with planned sales, large holders, 13F holders and financials beside them, so the short position, the daily flow, the settlement fails and what insiders are doing can be read together.

Each section has its own history table, a one-line summary of the latest figures and its own JSON and CSV links, and says when its source last updated.

This page follows Xilio Therapeutics (XLO), SEC CIK 1840233, listed on Nasdaq, classified by the SEC as pharmaceutical preparations. The cross-market tables live on the short interest and insider transactions hubs.

Source and updates

Short interest
FINRA consolidated short interestSource: FINRA.Twice a month, about eight business days after settlement. Latest 2026-10-15.JSON and CSV
Daily short volume
FINRA Reg SHO daily filesSource: FINRA.Every trading day, the morning after FINRA posts it. Latest 2026-11-02.JSON and CSV
Fails to deliver
SEC fails-to-deliver dataSource: SEC.Twice a month, a few weeks after the half month ends. Latest 2026-10-13.JSON and CSV
Large holders
SEC EDGAR Schedule 13D and 13GSource: SEC.New filings appear shortly after the SEC posts them. A 13D is due within five business days of crossing 5%; a 13G follows the passive schedule. Latest 2026-08-14.JSON and CSV
13F holders
SEC EDGAR Form 13F-HRSource: SEC.Quarterly, filed within 45 days of quarter end; 30 tracked managers. Latest 2026-06-30.JSON and CSV
Earnings dates
SEC EDGAR 8-K filings (Item 2.02)Source: SEC.Twice a day. Reported dates come from the company's 8-K filings; the next date is marked as an estimate until the 8-K arrives. Latest 2026-08-12.JSON and CSV
Insider trades
SEC EDGAR Form 4Source: SEC.New filings appear shortly after the SEC posts them; they're due two business days after the trade. Latest 2026-03-26.JSON and CSV
Company record
EDGAR filing index for CIK 1840233Ticker, name and exchange from the SEC's company list, refreshed weekly.
Rate limits
10 requests a minute without a key, 30 with a free key from a free account.

How to read it

  • Read the position against the flow: rising short interest with a high daily short share is new shorting; rising short interest with a normal short share is old shorts holding on.
  • Insider buys next to a large short position are rare and stand out; insider sells next to one are common and mean little.
  • Fails to deliver matter relative to the float, not in absolute shares; a million failed shares in a mega cap is noise.

Analysis of what the data shows, not advice. XOOMAR does not recommend buying, selling or holding anything.

Datasets

Frequently Asked Questions

How much of XLO is sold short?
400,316 shares were held short at the 2026-10-15 settlement, 41.2 days of average volume. FINRA publishes the next count about eight business days after the 15th and the last business day of the month.
What is XLO's daily short volume?
On 2026-11-02, 1,833 of the 3,501 XLO shares reported to FINRA were sold short, 52.4% of the day's reported volume. Short volume is a flow for one day, not a position.
Does XLO have fails to deliver?
The SEC's latest file shows 46 XLO shares failed to deliver at settlement 2026-10-13. Fails are reported per settlement date and published twice a month with a lag.
Are XLO insiders buying or selling?
No open-market insider trades were reported for XLO in the last 90 days. The most recent filings are listed below. Latest filing: Shannon James Samuel (Director) on 2026-03-26.
Who owns 5% or more of XLO?
17 holders report 5% or more of XLO in their latest filing, all on Schedule 13G (passive). The largest reported stake is GILEAD SCIENCES, INC. at 19.9% of the class (14,517,678 shares), filed 2026-02-12 for an event on 2025-12-31.
Which tracked 13F managers own XLO?
3 of the 30 tracked 13F managers held XLO shares at their latest filing, $1.0M in all. The largest: Renaissance Technologies (64K shares, $615K), Ken Griffin's Citadel Advisors (26K shares, $249K), Two Sigma Investments (15K shares, $139K).

Data on this page is provided for informational purposes only and is not financial advice. See our editorial policy.