XOOMAR

Denali Therapeutics (DNLI)

Denali Therapeutics on one page: short interest, daily short volume, fails to deliver, planned sales, large holders, 13F holders, financials, earnings dates and insider trades. Listed on Nasdaq, classified by the SEC as biological products, (no diagnostic substances).

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15.5M

Short interest

settlement 2026-09-30

7.6

Days to cover

-4.3 days vs prior

44.3%

Short share of volume

2026-10-09

39,910

Fails to deliver

settlement 2026-09-10

Thu 5 Nov

Next earnings

estimated date

-$435K

Insider flow, 90 days

0 buys, 5 sells

As of 2026-10-09.

Short interest

FINRA, twice a month. The newest 24 settlements in the table, 48 in the chart. JSON

As of 30 September 2026, short interest in DNLI is 15,463,975 shares, down 1,178,387 shares over the last month. Over the last 48 readings it ranged from 7,098,359 shares (15 November 2024) to 17,959,465 shares (14 August 2026). At the reported average volume of 2.0M shares a day that is 7.6 days to cover.

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SettlementShares shortChangeAvg daily volumeDays to cover
2026-09-3015,463,975-9.8%2,023,7147.64
2026-09-1517,139,415+3.0%1,431,79411.97
2026-08-3116,642,362-7.3%951,21617.50
2026-08-1417,959,465+3.0%1,446,97112.41
2026-07-3117,434,654+8.7%1,438,87812.12
2026-07-1516,035,916+0.5%1,910,7588.39
2026-06-3015,949,089+3.5%2,295,3826.95
2026-06-1515,407,744+2.8%1,827,1458.43
2026-05-2914,990,471+6.9%1,870,1188.02
2026-05-1514,026,925-5.3%1,867,5257.51
2026-04-3014,813,936-3.1%1,488,8309.95
2026-04-1515,284,401-0.9%1,384,89911.04
2026-03-3115,421,152+8.2%2,313,1946.67
2026-03-1314,258,580-0.4%1,496,1619.53
2026-02-2714,319,419+5.3%1,586,5289.03
2026-02-1313,594,971+0.3%1,560,9158.71
2026-01-3013,558,718-8.8%1,931,9407.02
2026-01-1514,858,586+2.0%1,535,6679.68
2025-12-3114,560,677+11.2%1,168,80412.46
2025-12-1513,092,563+0.9%2,129,5876.15
2025-11-2812,977,218-7.4%1,291,58610.05
2025-11-1414,017,386+6.9%1,547,3139.06
2025-10-3113,110,288-9.8%1,481,2938.85
2025-10-1514,527,782+2.7%1,705,4958.52

Daily short volume

FINRA Reg SHO, the last 30 sessions. JSON

As of 9 October 2026, the short share of DNLI volume is 44.3%, up 2.4 points over the last five sessions. Over the last 30 readings it ranged from 30.3% (2 September 2026) to 76.7% (6 October 2026). The latest reading is 8.4 points below the 30-session average of 52.7%, on 476K shares reported.

DateShort volumeTotal volumeShort shareExempt
2026-10-09211K476K44.3%22
2026-10-08251K495K50.8%1
2026-10-07248K459K54.2%2,766
2026-10-06912K1.2M76.7%998
2026-10-05310K550K56.4%0
2026-10-02257K613K41.9%0
2026-10-01389K652K59.7%0
2026-09-30367K647K56.8%0
2026-09-29217K486K44.6%0
2026-09-28468K950K49.2%1
2026-09-25263K514K51.2%225
2026-09-24538K977K55.1%0
2026-09-23404K635K63.7%1,533
2026-09-22469K852K55.0%7
2026-09-21307K988K31.0%100
2026-09-18231K567K40.7%0
2026-09-17231K505K45.8%0
2026-09-16338K661K51.1%0
2026-09-15617K812K76.0%32
2026-09-14180K354K50.8%0
2026-09-11308K448K68.7%0
2026-09-10179K297K60.2%0
2026-09-09346K819K42.3%0
2026-09-08229K600K38.1%0
2026-09-04171K283K60.6%382
2026-09-03272K586K46.4%2,075
2026-09-02216K713K30.3%0
2026-09-01249K492K50.6%11
2026-08-31128K226K56.6%74
2026-08-28173K238K72.5%69

Fails to deliver

SEC, the last 30 settlement dates with a fail. JSON

As of 10 September 2026, the fails-to-deliver balance in DNLI is 39,910 shares, up 39,234 shares over the last settlement date. Over the last 30 readings it ranged from 1 share (16 April 2026) to 179,418 shares (27 May 2026).

SettlementShares failedPriceValue
2026-09-1039,910$21.57$861K
2026-09-08676$22.28$15K
2026-09-045,459$22.80$124K
2026-09-038,776$22.85$201K
2026-08-25400$24.20$10K
2026-08-243,095$24.92$77K
2026-08-213,852$24.95$96K
2026-08-1831$24.35$755
2026-08-074,921$24.73$122K
2026-07-1640$23.02$921
2026-07-1392$25.68$2K
2026-07-02439$25.98$11K
2026-07-0160$25.72$2K
2026-06-30191$25.89$5K
2026-06-2628$24.73$692
2026-06-247,431$24.77$184K
2026-06-22315$23.31$7K
2026-06-15106$21.66$2K
2026-06-1149$20.61$1K
2026-06-10184$20.79$4K
2026-06-0830,328$19.52$592K
2026-06-031,327$19.35$26K
2026-06-022,722$20.41$56K
2026-05-27179,418$19.38$3.5M
2026-05-18217$18.62$4K
2026-05-088$19.71$158
2026-05-04411$18.30$8K
2026-04-3012$18.60$223
2026-04-161$21.68$22
2026-04-1559$20.16$1K

Insider trades

SEC Form 4, newest first, 50 of 100 shown. JSON

Insiders at DNLI reported 5 open-market sells worth $435K in the last 90 days and no open-market buys. Latest filing: Chin Peter Scott (Chief Medical Officer) on 2026-09-04.

DateInsiderTitleTypeSharesPriceValueOwned after
2026-09-04Chin Peter ScottChief Medical OfficerSell2K$22.29$37K205K
2026-09-02Thornberry NancyDirectorSell615$23.74$15K20K
2026-09-02Thornberry NancyDirectorSell11K$22.85$247K20K
2026-09-01Schuth Alexander O.COFO and SecretarySell3K$23.44$65K279K
2026-08-12Watts Ryan J.President and CEOGift32K$0.00$02.1M
2026-08-11Schuth Alexander O.COFO and SecretarySell3K$25.07$72K282K
2026-06-03Baker Brothers Life Sciences LPDirectorGrant6K$0.00$0343K
2026-06-03Van Hauwermeiren TimothyDirectorGrant6K$0.00$017K
2026-06-03Thornberry NancyDirectorGrant6K$0.00$031K
2026-06-03Krognes Steve E.DirectorGrant6K$0.00$038K
2026-06-03Schenkein David PDirectorGrant6K$0.00$022K
2026-06-03Klein Peter SDirectorGrant6K$0.00$034K
2026-06-03FLATLEY JAY TDirectorGrant6K$0.00$023K
2026-06-03Cook Jennifer E.DirectorGrant6K$0.00$032K
2026-06-03BAKER BROS. ADVISORS LPDirectorGrant6K$0.00$0343K
2026-01-06Schuth Alexander O.COFO and SecretarySell17K$16.50$284K283K
2026-01-06Watts Ryan J.President and CEOSell35K$16.50$581K297K
2026-01-03Schuth Alexander O.COFO and SecretaryGrant58K$0.00$0300K
2026-01-03Watts Ryan J.President and CEOGrant79K$0.00$0332K
2025-11-04Van Hauwermeiren TimothyDirectorGrant11K$0.00$011K
2025-09-03Watts Ryan J.President and CEOGift50K$0.00$02.2M
2025-08-13Ho CaroleChief Medical OfficerSell806$14.64$12K217K
2025-08-12Schuth Alexander O.COFO and SecretarySell3K$13.58$40K242K
2025-08-12Ho CaroleChief Medical OfficerSell3K$13.58$40K217K
2025-08-05Ho CaroleChief Medical OfficerOption exercise45K$0.68$30K220K
2025-07-09Watts Ryan J.President and CEOSell495K$15.00$7.4M253K
2025-07-09Watts Ryan J.President and CEOOption exercise40K$5.28$211K748K
2025-07-09Watts Ryan J.President and CEOOption exercise455K$0.68$310K708K
2025-06-03BAKER BROS. ADVISORS LPDirectorGrant11K$0.00$03.4M
2025-06-03Tessier-Lavigne MarcDirectorGrant6K$0.00$01.9M
2025-06-03Thornberry NancyDirectorGrant6K$0.00$025K
2025-06-03Schenkein David PDirectorGrant6K$0.00$015K
2025-06-03Krognes Steve E.DirectorGrant6K$0.00$032K
2025-06-03Klein Peter SDirectorGrant6K$0.00$028K
2025-06-03FLATLEY JAY TDirectorGrant6K$0.00$016K
2025-06-03Cook Jennifer E.DirectorGrant6K$0.00$026K
2025-06-03BAKER BROS. ADVISORS LPDirectorGrant11K$0.00$0337K
2025-01-07Krognes Steve E.DirectorSell3K$20.81$69K26K
2025-01-07Watts Ryan J.President and CEOSell8K$20.81$159K253K
2025-01-07Schuth Alexander O.COFO and SecretarySell3K$20.81$60K244K
2025-01-07Ho CaroleChief Medical OfficerSell3K$20.81$60K176K
2025-01-06Watts Ryan J.President and CEOSell29K$20.22$592K261K
2025-01-06Schuth Alexander O.COFO and SecretarySell12K$20.22$248K247K
2025-01-06Ho CaroleChief Medical OfficerSell12K$20.22$248K179K
2025-01-03Ho CaroleChief Medical OfficerGrant54K$0.00$0191K
2025-01-03Schuth Alexander O.COFO and SecretaryGrant54K$0.00$0259K
2025-01-03Watts Ryan J.President and CEOGrant54K$0.00$0290K
2025-01-02SATO VICKI LDirectorSell3K$20.91$64K108K
2024-12-31Krognes Steve E.DirectorSell30K$20.25$608K29K
2024-12-27Schuth Alexander O.COFO and SecretaryOption exercise7K$5.28$35K205K

Form 4 filings are due within two business days of the trade. Insiders sell for many reasons that say nothing about the company; open-market buys are rarer.

Planned sales (Form 144)

Newest first. JSON

9 Form 144 notices on file for DNLI worth $8.8M at the prices reported; 2 in the last 90 days worth $332K. Latest: NANCY THORNBERRY filed on 2026-09-02 to sell 11,439 shares ($266K) from 2026-09-02.

FiledSellerSharesMarket valueOf outstandingSale fromBroker
2026-09-02NANCY THORNBERRYDirector11K$266K0.007%2026-09-02Morgan Stanley Smith Barney LLC Executive Financial Services
2026-09-01ALEXANDER SCHUTHOfficer3K$66K0.005%2026-09-01Morgan Stanley Smith Barney LLC Executive Financial Services
2026-02-05CAROLE HOFormer Affiliate39K$801K0.027%2026-02-05Morgan Stanley Smith Barney LLC Executive Financial Services
2026-02-04CAROLE HOFormer Affiliate150K$3.2M0.102%2026-02-04Morgan Stanley Smith Barney LLC Executive Financial Services
2026-02-03CAROLE HOFormer Affiliate150K$3.3M0.102%2026-02-03Morgan Stanley Smith Barney LLC Executive Financial Services
2026-01-06Ho CaroleConsultant17K$284K0.011%2026-01-06Morgan Stanley Smith Barney LLC Executive Financial Services
2026-01-06Schuth Alexander O.Officer17K$284K0.011%2026-01-06Morgan Stanley Smith Barney LLC Executive Financial Services
2026-01-06Watts Ryan J.Director, Officer35K$581K0.023%2026-01-06Morgan Stanley Smith Barney LLC Executive Financial Services
2025-12-04CAROLE HOOfficer2K$36K0.001%2025-12-04Morgan Stanley Smith Barney LLC Executive Financial Services

Large holders (13D and 13G)

One row per reporting person with its latest filing, newest first. JSON

2 holders report 5% or more of DNLI in their latest filing, all on Schedule 13G (passive). The largest reported stake is T. Rowe Price Investment Management, Inc. at 10.2% of the class (16,178,963 shares), filed 2026-07-08 for an event on 2026-06-30.

FiledFormHolderSharesOf classEvent
2026-08-0413G/Ano. 8BAILLIE GIFFORD & COinvestment adviser12.0M7.5%2026-06-30
2026-07-0813G/Ano. 1T. Rowe Price Investment Management, Inc.investment adviser16.2M10.2%2026-06-30
2026-05-0613G/Ano. 3Abigail P. Johnsonindividual6.7M4.2%2026-03-31
2026-05-0613G/Ano. 3FMR LLCparent holding company6.7M4.2%2026-03-31
2026-03-2613G/Ano. 6The Vanguard Groupinvestment adviser00.0%2026-03-13

13F holders

Tracked managers holding DNLI at their latest 13F. JSON

4 of the 30 tracked managers held DNLI at their latest 13F, $102.8M in total at quarter-end prices. Fisher Asset Management is the largest at $62.1M (0.0% of its portfolio) as of 2026-06-30. Over the prior quarter 1 added shares and 3 cut.

FundQuarterSharesValueOf portfolioChange in shares
Fisher Asset Management2026-06-302.4M$62.1M0.02%-23K
Millennium Management2026-06-301.1M$29.0M0.01%-132K
AQR Capital Management2026-06-30388K$10.0M0.00%+286K
Citadel Advisors2026-06-3067K$1.7M0.00%-114K

Only the 30 tracked managers on the funds hub; a 13F reports long positions in US listed stock at quarter end, 45 days late, and says nothing about shorts or positions sold since.

Financials

SEC XBRL, as filed. JSON

In Q2 FY 2026 (quarter ended 2026-06-30) Denali Therapeutics reported revenue of $3.6M, and net loss of $127.6M (-0.68 diluted EPS). In FY 2025 it generated -$412.6M of operating cash flow.

Cash
$201.5M
Equity
$835.2M
Total assets
$1.16B
Shares outstanding
159,847,403

Quarterly, last 8 quarters

QuarterPeriod endRevenueNet incomeMarginDiluted EPS
Q2 FY 20262026-06-30$3.6M-$127.6M-3539.2%-0.68
Q1 FY 20262026-03-31n/a-$128.4Mn/a-0.69
Q4 FY 2025derived2025-12-31n/a-$128.5Mn/an/a
Q3 FY 20252025-09-30n/a-$126.9Mn/a-0.74
Q2 FY 20252025-06-30$0-$124.1Mn/a-0.72
Q1 FY 20252025-03-31n/a-$133.0Mn/a-0.78
Q4 FY 2024derived2024-12-31$0-$114.8Mn/an/a
Q3 FY 20242024-09-30$0-$107.2Mn/a-0.63

Fiscal years, with buybacks and dividends

Fiscal yearEndsRevenueNet incomeOperating cash flowCapexBuybacksDividends
FY 20252025-12-31$0-$512.5M-$412.6M$9.5Mn/an/a
FY 20242024-12-31$0-$422.8M-$347.7M$15.9Mn/an/a
FY 20232023-12-31$330.5M-$145.2M-$358.0M$12.9Mn/an/a
FY 20222022-12-31$105.1M-$326.0M-$244.7M$17.8Mn/an/a
FY 20212021-12-31$48.7M-$290.6M-$211.4M$8.5Mn/an/a

Quarters are the three-month figures the company reports; a fourth quarter marked derived is the fiscal year less the three reported quarters, since companies report it only inside the 10-K. Fiscal years are the annual figures. Buybacks are the cash the company paid to repurchase its common stock in the year, not the amount authorized. Balance sheet lines are as of 2026-06-30; shares outstanding as of 2026-07-31 from the cover page.

What this page is

Denali Therapeutics in the regulatory record

Regulators publish company data in separate files that never sit next to each other: FINRA's twice-monthly short interest, its daily short sale volume, the SEC's fails-to-deliver counts, and each insider's Form 4. A company page puts those series for one ticker on one URL, with planned sales, large holders, 13F holders and financials beside them, so the short position, the daily flow, the settlement fails and what insiders are doing can be read together.

Each section has its own history table, a one-line summary of the latest figures and its own JSON and CSV links, and says when its source last updated.

This page follows Denali Therapeutics (DNLI), SEC CIK 1714899, listed on Nasdaq, classified by the SEC as biological products, (no diagnostic substances). The cross-market tables live on the short interest and insider transactions hubs.

Source and updates

Short interest
FINRA consolidated short interestSource: FINRA.Twice a month, about eight business days after settlement. Latest 2026-09-30.JSON and CSV
Daily short volume
FINRA Reg SHO daily filesSource: FINRA.Every trading day, the morning after FINRA posts it. Latest 2026-10-09.JSON and CSV
Fails to deliver
SEC fails-to-deliver dataSource: SEC.Twice a month, a few weeks after the half month ends. Latest 2026-09-10.JSON and CSV
Planned sales
SEC EDGAR Form 144Source: SEC.New notices appear shortly after the SEC posts them; a notice is filed on or before the sale. Latest 2026-09-02.JSON and CSV
Large holders
SEC EDGAR Schedule 13D and 13GSource: SEC.New filings appear shortly after the SEC posts them. A 13D is due within five business days of crossing 5%; a 13G follows the passive schedule. Latest 2026-08-04.JSON and CSV
13F holders
SEC EDGAR Form 13F-HRSource: SEC.Quarterly, filed within 45 days of quarter end; 30 tracked managers. Latest 2026-06-30.JSON and CSV
Financials
SEC EDGAR 10-K and 10-Q filingsSource: SEC.Weekly; values are as filed in the 10-Q and 10-K. Latest 2026-06-30.JSON and CSV
Earnings dates
SEC EDGAR 8-K filings (Item 2.02)Source: SEC.Twice a day. Reported dates come from the company's 8-K filings; the next date is marked as an estimate until the 8-K arrives. Latest 2026-02-26.JSON and CSV
Insider trades
SEC EDGAR Form 4Source: SEC.New filings appear shortly after the SEC posts them; they're due two business days after the trade. Latest 2026-09-04.JSON and CSV
Company record
EDGAR filing index for CIK 1714899Ticker, name and exchange from the SEC's company list, refreshed weekly.
Rate limits
10 requests a minute without a key, 30 with a free key from a free account.

How to read it

  • Read the position against the flow: rising short interest with a high daily short share is new shorting; rising short interest with a normal short share is old shorts holding on.
  • Insider buys next to a large short position are rare and stand out; insider sells next to one are common and mean little.
  • Fails to deliver matter relative to the float, not in absolute shares; a million failed shares in a mega cap is noise.

Analysis of what the data shows, not advice. XOOMAR does not recommend buying, selling or holding anything.

Datasets

Frequently Asked Questions

How much of DNLI is sold short?
15,463,975 shares were held short at the 2026-09-30 settlement, 7.6 days of average volume. FINRA publishes the next count about eight business days after the 15th and the last business day of the month.
What is DNLI's daily short volume?
On 2026-10-09, 210,855 of the 475,904 DNLI shares reported to FINRA were sold short, 44.3% of the day's reported volume. Short volume is a flow for one day, not a position.
Does DNLI have fails to deliver?
The SEC's latest file shows 39,910 DNLI shares failed to deliver at settlement 2026-09-10. Fails are reported per settlement date and published twice a month with a lag.
Are DNLI insiders buying or selling?
Insiders at DNLI reported 5 open-market sells worth $435K in the last 90 days and no open-market buys. Latest filing: Chin Peter Scott (Chief Medical Officer) on 2026-09-04.
Have DNLI insiders filed to sell?
9 Form 144 notices on file for DNLI worth $8.8M at the prices reported; 2 in the last 90 days worth $332K. Latest: NANCY THORNBERRY filed on 2026-09-02 to sell 11,439 shares ($266K) from 2026-09-02.
Who owns 5% or more of DNLI?
2 holders report 5% or more of DNLI in their latest filing, all on Schedule 13G (passive). The largest reported stake is T. Rowe Price Investment Management, Inc. at 10.2% of the class (16,178,963 shares), filed 2026-07-08 for an event on 2026-06-30.
What did DNLI report last quarter?
In Q2 FY 2026 (quarter ended 2026-06-30) Denali Therapeutics reported revenue of $3.6M, and net loss of $127.6M (-0.68 diluted EPS). In FY 2025 it generated -$412.6M of operating cash flow.
Which tracked 13F managers own DNLI?
4 of the 30 tracked 13F managers held DNLI shares at their latest filing, $102.8M in all. The largest: Ken Fisher's Fisher Asset Management (2.4M shares, $62.1M), Izzy Englander's Millennium Management (1.1M shares, $29.0M), Cliff Asness's AQR Capital Management (388K shares, $10.0M), Ken Griffin's Citadel Advisors (67K shares, $1.7M).

Data on this page is provided for informational purposes only and is not financial advice. See our editorial policy.